锐晋医学,克利夫兰诊所访问学者

克利夫兰诊所招收晚期前列腺癌研究博士后

克利夫兰诊所招收晚期前列腺癌分子机能与平移研究博士后,要求申请者持有博士学历,有分子生物学、化学、代谢或癌症生物学等相关专业背景,英语口语及书面语沟通能力佳。感兴趣的申请者请准备博士后个人简历和三封推荐信等国外访问学者博士后申请常用材料。

添加时间:2018-11-13

详细介绍

  克利夫兰诊所招收晚期前列腺癌分子机能与平移研究博士后,要求申请者持有博士学历,有分子生物学、化学、代谢或癌症生物学等相关专业背景,英语口语及书面语沟通能力佳。感兴趣的申请者请准备博士后个人简历和三封推荐信等国外访问学者博士后申请常用材料。

  小编还想提醒您的是,该博士后职位将为申请者提供肿瘤代谢、分子肿瘤、药物研发与临床实验等研究领域一流的科研环境及跨学科研究平台。关于克利夫兰诊所博士后申请材料的问题,您还想了解什么?

  Molecular Mechanisms and Translational Investigation of Advanced Prostate Cancer

  Cleveland Clinic, Cleveland, OH

  A postdoctoral fellowship position supported by the National Institutes of Health and the Prostate Cancer Foundation are available in the laboratory of Dr. Nima Sharifi at the Cleveland Clinic.

  Our laboratory is focused on metabolic and molecular mechanisms of androgen synthesis and androgen receptor (AR) gain-of-function that lead to resistance to hormonal therapy. Specific areas include:

  1) Metabolic and genetic changes required for hormone therapy resistance in prostate cancer and tumor progression

  2) Clinical validation in patients and clinical trials utilizing innovative approaches

  3) Animal models of advanced prostate cancer for translational and therapeutic studies

  4) Identifying targets for the development of new pharmacologic therapies

  We discovered the first example of a gain-of-function in a steroid-synthesizing enzyme that enables prostate cancer resistance to hormonal therapy (Chang, et al. Cell. 2013 154(5):1074-1084) and that we have shown in a predictive biomarker of poor outcomes after hormonal therapy (Hearn, et al. Lancet Oncol. 2016 17(10):1435-44; Hearn, et al. JAMA Oncol. 2018 Apr 1;4(4):558-562). We are current evaluating this biomarker in a clinical trial and are pursuing similar mechanisms and developing new treatment modalities based on these discoveries.

  We recently also discovered that abiraterone works by conversion to a more active steroidal metabolite (Li, et al. Nature. 2015 523(7560):347-51), that metabolism is pharmacologically modifiable to optimize therapy (Li, et al. Nature. 2016 533(7604):547-51), that this is a class effect of steroidal androgen synthesis inhibitors (Alyamani, et al. Cell Chemical Biology. 2017 24, 1-8, July 20) and genetic determination of metabolite generation (Alyamani, et al. J Clin Invest. 2018 Aug 1;128(8):3333-3340).

  The position will provide a unique and multidisciplinary exposure to tumor metabolism, molecular oncology, drug development and clinical trials. Further details are available at the following link: https://www.lerner.ccf.org/cancerbio/sharifi/#lab

  Candidates should hold a doctoral degree with a background in molecular biology, chemistry, metabolism or cancer biology. Candidates must have proficiency in verbal and written English.

  Candidates with an interest in the position should send their CV and contact information for 3 references to:

  Nima Sharifi, M.D.

  Kendrick Family Chair for Prostate Cancer Research

  casalek@ccf.org

  克利夫兰医学中心简介

  克利夫兰医学中心是世界最著名医疗机构之一,机构集合医疗、研究和教育三位一体,提供专业医疗和最新治疗方案的非营利性机构。克利夫兰医学中心始建于1921年2月28日,隶属于俄亥俄州一家非营利性公司——克利夫兰临床基金会,并由其经营。

  克利夫兰医学中心本部位于克利夫兰市,在佛罗里达、内华达、加拿大和阿布扎比开设有分院。克利夫兰诊所本部共有超过1400个床位,整个医院体系拥有4400个床位。
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